Yep. Compared to natural, spontaneous conception, IVF is associated with an increased risk of problems such as fetal abnormalities, due to:
(a) inherent issues with the IVF process,
(b) the tendency for older women, especially those with underlying infertility issues, to use IVF; and to a lesser but significant extent,
(c) the tendency for older men, including those with underlying infertility issues, to use IVF.
Studies of Assisted Reproduction
Increased risk of various negative outcomes reported across most studies tend to vary from 1% to 50%, with some studies showing 100% - 200% greater risk for rarer conditions. Example studies are quoted below.
*Note. An odds ratio (OR) of 1.15 means the exposure being studied is associated with 15% higher odds of the outcome occurring compared to the reference group.
Influence of Parental Characteristics
Note that fathers are not exempt
Implications
This research has some implications in relation to the broader topic of this thread. These implications are also informed by my wider knowledge and personal experience (older father, in my 40's, wife in her 20's).
- Younger women are objectively more desirable, not just based on physical appearance or a lack of emotional baggage, but also due to their better health and fertility
- Older women (30 - 35+) are more likely to seek IVF, are less capable of carrying a healthy pregnancy to full term naturally, and when they do give birth, their children are more likely to have medical complications:
https://academic.oup.com/humupd/article-abstract/11/3/261/759255?redirectedFrom=fulltext. Many women are not up to speed with these medical realities:
https://www.racgp.org.au/afp/2012/may/making-decisions-about-fertility
- Although the age of women is a stronger factor in determining the viability of pregnancy compared to age of men, older men (35 - 45+) are still likely to have more issues pre-conception due to degraded sperm quality, DNA damage, etc, and to have more problems with their children's health**
https://med.stanford.edu/news/all-n...rs-associated-with-increased-birth-risks.html
** Caveats. This doesnt touch on the challenges for older parents once the baby arrives - e.g., lower energy, more health issues, etc. Developing wealth over time does improve quality of life, increases social status, and makes men more attractive. However it's not an elixir to solve all problems associated with aging, large age gaps, unrealised personal development, etc. Some of these issues have been explored here:
https://christisking.cc/threads/marriage-virgins-vs-non-virgins.850/page-3#post-38821
Here's the thread to continue the IVF discussion:
https://christisking.cc/threads/in-vitro-fertilization.1097/