Thanks but this is a very generic statement. Many times sleeping on various mattresses in various positions or firmness can be bad, and it's hard to know until you are on them for 8 hours.Musculoskeletal problems are symptoms that often have multiple underlying causes, one of them being diet.
Anything in particular that you think one should be doing with seat, heigh, pedal, legs?
Here's the thing I find so bizarre about it, and yes everyone can be better and should be stretching and more flexible: how do you go from sitting a long time around the house, in computers, in other cars, etc (and I work out and have strong big lifts, etc) to riding in a car for an hour and the low back is strained? Clearly it has to do with the new position and cushion (I think it's this as others have said it on reddit commonly). It's not like it was a 5 hour drive. I've done those in other comfortable rides and not had symptoms. New seat is the problem, by definition.